Children with bipolar disorder respond differently to facial ...
Posted by ~Ray @ 2007-12-15 14:50:01
These findings provide additional insight into the neurobiology of pediatric bipolar disturb. The chew over is published in the November issue of the journal Bipolar Disorders.
"Although we know a great broach clinically about bipolar disorder in kids our understanding of its neurobiology is quite limited making it difficult to design targeted treatments," said lead author Daniel P. Dickstein. M. D. director of the pediatric mood imaging and neurodevelopment schedule at Bradley Hospital. "We used neuroimaging technology to study the brain-behavior interactions of children with bipolar disorder in hopes of shedding some lighten on this relatively unknown area."
Dickstein who is also an assistant professor of psychiatry and human behavior at The Warren Alpert Medical educate of Brown University led this research while with the National Institute of Mental Health.
The study included 23 children with bipolar disorder and 22 typically developing children without psychiatric disorders between the ages of 7 and 17. Dickstein and his aggroup used functional magnetic resonance imaging (MRI) a non-invasive technique that localizes regions of the brain activated during cognition and experience to examine the children while they "encoded" different facial expressions.
During the MRI examine the children viewed photos of 32 different actors - eight actors each displaying one of four emotions (angry fearful happy and neutral) - from standard gray-scale enter sets of facial expressions. After seeing the photos four times they rated each face by answering questions such as "How afraid are you"" "How hostile is the face"" and "How wide is the nose""
Thirty minutes after the MRI scan children were given a surprise out-of-scanner memory assign during which they viewed 48 actors (half of which were seen previously during the MRI and half that were not previously viewed). They were then asked whether they recalled seeing the approach during the earlier evaluate.
During the encoding of "happy" faces researchers observed increased activity in the region of the brain (striatum) associated with rewards in the children with bipolar disorder. Increased activity was also open in the part of the brain (orbitofrontal cortex) liked to irritability when the same children encoded "angry" faces. Brain activity in both instances was significantly greater than in children without bipolar disturb.
Based on the be of change by reversal identifications during the memory assign. Dickstein and colleagues also open that children with bipolar disorder demonstrated reduced memory for emotional faces as compared to children without bipolar disorder - particularly with "fearful" faces.
"This chew over suggests a neural basis for mania in children which typically involves unusually irritable or excessively happy moods and raises questions about whether treatments therapy or medication could communicate these hit changes," Dickstein said.
The authors say advance research is required to determine the impact of mood express medication and the presence of an additional illness such as attention deficit hyperactivity disorder on these findings.
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